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Most gastrointestinal side effects with both medications occur during dose escalation and reduce significantly over time

Local injection site reactions may include: Persistent redness, swelling, or induration at injection sites Itching or burning sensation that extends beyond typical injection discomfort Delayed reactions occurring hours to days after administration Nodule formation or skin changes at injection sites These local reactions differ from common injection site responses, which typically resolve within days and occur as expected medication effects rather than antibody-mediated responses

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