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As a result, exenatide increased HR by a mean maximum of 6.8 beats per minute (bpm), as well as systolic BP by 9.8 mm Hg [38]

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Oral semaglutide was then investigated in eight global Peptide InnOvatioN for the Early diabEtes tReatment (PIONEER) phase IIIa trials in over 8,000 patients, with similarly broad evaluation in different patient populations who were receiving a range of background medications ( Table 1 )

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