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These drugs can increase risk of serious infection and cancer (NIH 2013

Exp Gerontol 43:370377 Shen H, Oesterling E, Stromberg A, Toborek M, MacDonald R, Hennig B (2008) Zinc deficiency induces vascular pro-inflammatory parameters associated with NF-kappaB and PPAR signaling

It crosses the blood-brain barrier more effectively than other forms of carnitine, which allows it to exert its effects within the brain

Therefore, collectively, these findings suggest that administering NAD + precursors prevents oxidative stress and mitochondrial dysfunction, and hence may be a useful therapeutic target for ALS