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Monitor urine color as a hydration indicatorpale yellow suggests adequate hydration, while dark yellow or amber indicates the need for more fluids Increase fluid intake during episodes of nausea, vomiting, or diarrhea to compensate for losses and prevent dehydration Sip water throughout the day rather than consuming large volumes at once, which may worsen nausea Consider oral rehydration solutions (available over-the-counter) if experiencing persistent diarrhea or vomiting, as these replace both fluids and electrolytes Moderate caffeine intake , as it can have mild diuretic effects, though regular caffeine consumers typically develop tolerance to this effect Patients experiencing persistent nausea may find it challenging to maintain fluid intake

This side effect results from semaglutides mechanism of slowing gastrointestinal motility and gastric emptying

Adhami VM, Syed DN, Khan N, Mukhtar H

The GHK component refers to the tripeptide sequence of three amino acids: glycine, histidine, and lysine