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Primary Endpoint Disease-free survival (DFS) Secondary Endpoints: Loco-regional failure-free survival (LRFS), distant metastasis-free survival (DMFS), overall survival (OS), pathological complete response (pCR), R0 resection rate, toxicity, and post-surgical complications Results In the largest randomized trial to date assessing irinotecan-enhanced chemoradiation in MRI-defined locally advanced rectal cancer, no significant improvement was seen in disease-free survival or other oncologic endpoints

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The protective effect of SIRT3 in glomerulopathy is related to the increased levels of SIRT3 and Nampt

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