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While emergent evidence suggests the benefits of GLP-1 RA-based interventions in psychiatric populations, their comparative benefits and comparative safety profiles within these vulnerable individuals remain largely unclear

The mean 9.4% BW reduction exhibited by patients treated with OW semaglutide 2.4 mg might partially explain the HF benefit observed in this trial 84 , as previously demonstrated for treatments leading to at least 10% weight loss 87

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For some, these risks might be too much, while others will take them for the possibility of improved outcomes