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(2018) reported clinically meaningful worsening of Parkinsons disease symptoms in patients receiving high-dose oral NAC, with symptom resolution following treatment discontinuation, suggesting a potential dose-dependent adverse effect

transient elastography (FibroScan) may be used in some pathways to evaluate liver stiffness as a marker of fibrosis

Additional enrichment analyses were conducted for cell-type markers (via Fishers exact test) and Gene Ontology (GO) terms using the clusterProfiler R package

Data obtained from several trials and meta-analysis studies on beta-carotene and vitamin E (ATBC trial) indicate that while vitamin E is not effective in cancer prevention, beta-carotene may even increase the incidence of lung cancer among smokers (see also above)