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Table of Contents What Is GLP1 and Why It Matters How the GLP1 Mechanism of Action Works Effects on Glucose Metabolism Impact on Appetite and Body Weight Cardiovascular Actions Beyond Metabolism: Liver and Brain Effects Clinical Implications for Everyday Practice Frequently Asked Questions What Is GLP1 and Why It Matters Glucagonlike peptide1 (GLP1) is an incretin hormone released by intestinal Lcells in response to food intake