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It has multiple, interconnected roles: Blood sugar regulation: Stimulates insulin release from the pancreas in a glucose-dependent way, reducing the risk of blood sugar episodes like spikes and crashes

Despite the wealth of evidence that characterizes the metabolically unfavorable changes in hepatic pathways linked to estrogen deficiency (8, 13), the potential for estrogen-based hormone replacement therapy (HRT) to limit the development of MASLD has not been rigorously tested

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