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Both plasma GLP-2 and ileal Gcg mRNA levels were restored upon 2 days of refeeding or 4 days of continuous intragastric, but not intravenous, refeeding with total parenteral nutrition (TPN) solution (32% energy from fat 68% energy from dextrose) (Nelson et al., 2008)

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Who May Be at Higher Risk for Weight Regain and How to Prepare Patients with type 2 diabetes, polycystic ovary syndrome (PCOS), metabolic syndrome, or strong family history of obesity face higher weight regain risk due to underlying insulin resistance and dysregulated appetite signaling