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On April 30, 2026, the FDA announced a formal proposal - published in the Federal Register - to exclude semaglutide and tirzepatide from the 503B outsourcing compounding list, with a public comment period open through the end of June 2026

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Enthusiasts sometimes counter that BPC-157 is natural because its sequence derives from a gastric protein, but the marketed compound is a synthetic partial sequence, and derived from a human protein is not a safety or efficacy credential