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Retrospective studies of GLP-1 therapy support the role of structured exercise programs, e.g., 360 min/week with an emphasis on strength exercises to preserve fat-free mass [161]

IGF-1 and the muscle question The biggest worry with rapid weight loss is that some of what you lose is muscle, not fat

Common GLP-1 Inhibitors Some of the most commonly prescribed GLP-1 inhibitors include: Semaglutide (Ozempic, Wegovy, Rybelsus) Liraglutide (Victoza, Saxenda) Dulaglutide (Trulicity) Tirzepatide (Mounjaro) Exenatide (Byetta, Bydureon) These medications are most commonly administered in the form of weekly injections, but there are a few oral formulations available on the market as well

Furthermore, periconception safety and complications rely on registries and retrospective cohorts, where confounding factors cannot be ignored (48, 132)