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For a low-side-effect, pulsatile GH augmentation that respects physiologic rhythm, ipamorelin is the cleaner choice

The overall effects of these alterations are increased emotional hyperactivity (orbitofrontal and basolateral hyperactivity of the amygdala not moderated by the central amygdala equipped with a robust network of GABAergic neurons), memory lability (hippocampal hypotrophy), and cognitive and environmental self-regulation difficulties (mPFC and hippocampal hypotrophy and, consequently, of salience networks, which is based on these areas)

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Virology 413 , 265274 (2011)