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Wang D, Day EA, Townsend LK, Djordjevic D, Jrgensen SB, Steinberg GR

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(2020) illustrated that NAC safeguards hippocampal neurons against oxidative stress-induced damage in a rat model of depression by inhibiting p38/JNK and concurrently promoting ERK signaling pathways, thereby emphasizing NACs significant neuroprotective role through MAPK inhibition [47]

However, because the lips are constantly in motion and we often "eat" our lip products throughout the day, topical application alone may not be enough to sustain high levels of the nutrient in the skin tissue