The PPPs integration with CRC metabolism is exemplified through cysteine metabolism, a glutathione synthesis prerequisite requiring substantial NADPH from PPP-mediated cystine-to-cysteine conversion
Additionally, Medicaid coverage of GLP-1 medications for obesity varies across states, leaving many patients ineligible for coverage depending on where they live
BCRP expression can be traced to placenta, kidney, liver, testis, brain, mammary tissue, and intestine (Doyle and Ross 2003)
Screening and data extraction Two reviewers (RN and AMR) independently extracted the authors name, study design (parallel or cross-over), year of publication, number of participants, baseline BMI, % female, mean age, intervention and comparator characteristics, duration and the dosage of intervention, dropouts, degree of adherence to the intervention and mean and corresponding sd of change from baseline weight in each study arm