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Nine (64%) were 5-year exclusivities awarded for approval of new chemical entities, while the other 5 (36%) were 3-year exclusivities awarded for approval of new investigations or combinations

The decline in proteasome activity can have a protective cellular effect, since immediately following an oxidative insult, disassociation of the 19S regulator from the 26S proteasome complex occurs, leading to a large increase in 20S cellular concentration (Raynes et al, 2016a)

It is not clear whether the TrumpRx program will require this or not

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