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The EDICT study, employing diabetes medications (GLP-1 receptor agonist, pioglitazone, metformin) that correct the basic underlying pathophysiologic defects present in type 2 diabetes, convincingly demonstrated that combination therapy produces a greater and more durable reduction in HbA1c than the treat-to-fail approach using diabetes medications (sulfonylureas, metformin, insulin) that do not correct the basic metabolic and cellular defects (insulin resistance and beta-cell dysfunction) present in type 2 diabetes patients

This gradual decrease can manifest as fatigue, reduced muscle mass, increased body fat, diminished libido, and cognitive fog

Existing data also suggest the remarkable potential of tryptophan-derived aryl hydrocarbon receptor agonists, indole derivatives on lumen equilibrium (Zhang et al., 2021)

Succinobucol (AGI-1067) is a succinate ester derivative of probucol showing decreased HDL-lowering ability