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Increased Oxidative Stress Alcohol consumption triggers a surge of free radicals

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On the other hand, it has been reported that THs can stimulate the synthesis and release of hepatic IGF1 in both fish and mammals (207209), which through the longloop negative feedback ( Figure 1 ) could elicit a suppression of pituitary GH secretion

Figure 2 shows the cytosolic concentration of GSH in our model liver cells for 10 hours after the concentration of the enzyme GCS was set to zero