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The COXEN principle: translating signatures of in vitro chemosensitivity into tools for clinical outcome prediction and drug discovery in cancer
The TB-500 component (thymosin -4) is a prohibited substance under WADA Section S2 (Peptide Hormones, Growth Factors, Related Substances and Mimetics), prohibited at all times
In the landmark 2017 study, FOXO4-DRI selectively induced apoptosis in senescent human fibroblasts (IMR90 cell line) while sparing non-senescent cells at an 11.73-fold selectivity ratio
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