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US survey data from the NHANES What We Eat in America 2013e16 cohort reported the median vitamin B12 consumption for all adult men of 5.1 mcg and women of 3.5 mcg.95b Using the Estimated Average Requirement (EAR) for adults for Vitamin B12 of 2 mcg,93 less than 3% of men and 8% of women in the United States had inadequate diets using this comparator

This reaction effectively diverts nicotinamide away from the NAD+ salvage pathway, reducing the cell's capacity to regenerate NAD+

This is a compounded preparation made by a licensed pharmacy and has not undergone FDA evaluation for safety, efficacy, or manufacturing quality

doi:10.1007/978-0-387-78518-9_18