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Until then, retatrutide remains an investigational compound available only through research channels

Semaglutide, the next FDA-approved GLP-1RA medication, demonstrates greater weight loss in patients with obesity, mediated by its increased half-life compared to liraglutide through modification to inhibit degradation by dipeptidyl-peptidase-4 (DPP-4) [38]

Very recently, GLP1 monotherapies have also been applied in the pharmacological management of PCOS, with promising results 32 , which are yet to be consolidated in clinical practice

Semaglutide injections start at $199/mo, but the cost increases as your dose goes up, reaching $299/mo at higher doses