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CMAJ Canadian Med Assoc J 172(9):11991209

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The heme group characterized in the active sites of crystal structures of two large subunit size catalases, catalase (PVC) and HPII from , has the structure of the cis-hydroxy -spirolactone and is rotated 180 degrees about the axis defined by the --meso carbon atoms, with regard to the orientation found for heme in small subunit size catalases like bovine liver catalase (BVC) [29]

Clinical scores were analyzed as repeated measurements using a method of residual maximum likelihood (REML), as implemented in Genstat version 22