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Description

L., Schatschneider, C., & Stanwood, G

.arcmed.2008.06.005 91

The GLP-1 peptide found in all other mammalian species binds the human GLP-1R with an IC50 of 7.9 10 10 M (Table 2), whereas the monotreme GLP-1 peptides bind the human and platypus GLP-1R with 50 fold lower affinity

Although the overall study findings were neutral, when patients enrolled in Russia and Georgia who likely did not have HFpEF were excluded, there was a significant reduction in the primary outcome among patients in the Americas