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Sulfonylureas, first under investigation in the 1940s as antibacterial agents, and TZDs, investigated in the 1980s as a lipid lowering therapies, were observed to induce hypoglycemia in animal models, and were then repurposed as antidiabetic drugs (95,96)

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It was night sweats, wild mood swings, and, ironically, significant hair loss that first sent Kate, 54, a New Yorkbased hairstylist, to her doctor in her late 40s looking for relief