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It is typically worst during the first few weeks and during dose escalations

Although most studies suggest that GLP-1RAs promote weight loss mainly due to their inhibitory effect on food intake, other central effects that have been described for native GLP-1 and some GLP-1RAs in rodents and humans encourage future clinical trials to explore additional mechanisms that potentially underlie the beneficial effects observed with this drug class

Randomized, double-blind, placebo-controlled, 24 weeks, n=86

Her story captures an important reality supported by early studies: while both medications are effective, their side effects can differ from one person to another