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In practice, these differences are usually minor and fall within the range of individual variation, but they add a layer of uncertainty that pharmaceutical products do not have

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study Nature Medicine 2019;25(7):1096-1103 doi:10.1038/s41591-019-0495-2 (Human trial, small) Suenaert P, Segers A, Rymenans L, et al

4 Pancreasmicrobiota interactions The application of multi-omics approaches to the study of the pancreas provides the foundation for developing personalized therapeutic strategies tailored to the molecular and cellular profiles of individual patients (Mou et al., 2025)