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TLR2 agonists significantly increase the proliferation of epithelial cell lines through multiple protein kinase pathways, and such experimental results were further confirmed by experiments in TLR2-deficient mice, where epithelial value-added was reduced in TLR2-deficient mice (46), and this effect would potentially impact on esophageal mucosal injury and repair

Gutzwiller JP, Gke B, Drewe J, Hildebrand P, Ketterer S, Handschin D, et al

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