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API Supply Chain Considerations If the FDA ultimately moves these substances into Category 1, there may be supply chain obstacles that could delay their practical availability

As direct validation of target proteins with recombinant enzymes in vitro was challenging, we favoured the native activation of 5-nitroimidazoles as a key step to evaluate their target preferences and deliberately avoided artificial activation mechanisms by, for example, chemical reduction in vitro 27,45

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Stick to bananas, rice, applesauce, peeled and grated apple, and toast (BRAT diet)