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Lipid peroxidation is a free radical chain reaction, mediated by lipoxygenases such as arachidonate 15-lipoxygenase, which recognizes the double-bond sites of PUFAs in membrane phospholipids and converts them into lipid hydroperoxides [57, 61]

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Gene editing can introduce point mutations to specifically modify O-GlcNAcylation sites [60], Nanobodies can be fused with engineered OGT or splitOGA to install or remove O-GlcNAc on target proteins within living cells [196]