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Environmental and Other Potential Factors: While environmental exposure has been proposed as a potential factor, robust evidence linking specific chemicals, toxins, or environmental factors to MPNST remains limited
found that TMAO promoted the release of pro-inflammatory cytokines such as IL-1 and TNF- to stimulate the cardiac autonomic nervous system (CANS) and worsen ischemia-induced VA (127)
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These findings support a model in which cold lethality of the slcr-46.1 mutant is not attributable to general sickness, but rather occurs in a copper-iondependent manner
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