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For subsequent mechanistic experiments, we used 600 M as a working approximation of the IC50 concentration

doi: 10.1038/s41380-018-0104-7 62

Development of kidney disease is associated with the enzyme myeloperoxidase (MPO), abundant in neutrophils catalyzing the transformation of hydrogen peroxide (H 2 O 2 ) to hypochlorous acid (HOCl), a powerful oxidizing cytotoxic agent, according to the reaction HOCl has been found to be responsible for renal dysfunction among obese children