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Because they're classed as food supplements rather than medicines, they don't require a prescription and aren't subject to the same rules as regulated treatments

The GLP-1 that does reach the pancreas calls for the release of more insulin when food is being broken down and absorbed

107 These effects all result in a slower and steadier uptake of nutrients into the circulation

While some studies found no difference between individuals with T2DM and matched non-diabetic controls ( per se and glycaemic control, since it is unclear whether changes in soluble DPP-4 activity in the circulation accurately reflect any changes in total DPP-4 activity