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It delivers its signal, triggers the desired response, and then clears out, letting the system reset for the next pulse

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Denicola et al., 2016)

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The ultimate pathways whereby these molecular changes may translate into changes in body weight and metabolic (dys)function are yet to be fully disclosed, but alterations in the hypothalamic proteome involved in inflammatory and apoptotic processes, as well as in autophagy and vesicular trafficking, may play a role

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