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In 2023, it was the top-selling drug in the U.S

Estradiol, in particular, exerts potent antioxidant effects by suppressing NADPH oxidase and exerts anti-inflammatory actions by inhibiting NF-B translocation in vascular smooth muscle cells and macrophages (119, 120)

Safety, Provider Oversight, and Who Should Consider Compounded GLP-1 Compounded semaglutide carries the same safety profile and contraindications as branded formulations: medullary thyroid carcinoma history, Type 1 diabetes, pancreatitis risk, and pregnancy require provider evaluation

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