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It is studied for its potential role in regulating sleep architecture and neuroendocrine signaling

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As mentioned above, NOS has significant neurotoxic impacts, and acts as a neuroprotective agent through mediation of vasodilation, plays a role in platelet aggregation inhibition, and contributes to endothelial leukocyte adhesion (Huang, 2007), and the studies above provide evidence and further support that disruptions to circadian rhythms support and increase neurotoxic effects and dampened neuroprotective aspects of NOS