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Protocols commonly use 200500 mcg subcutaneously, once or twice daily, in 46 week cycles, but there is no FDA-approved product or official dosing

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So when the barrier becomes more permeable, the proposed mechanism is straightforward: substances that should stay in the gut lumen bacterial fragments, undigested food particles, pathogens cross into deeper tissue and the bloodstream, where they can drive immune activation and an increased antigenic and toxic load