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While potentially being sufficient for the early rise in circulating GLP-1 upon food intake, the relative scarceness of L-cells in the proximal small intestine of both rodents and humans [208] suggests that proximal to-distal neuronal and/or humoral signals might affect the release of GLP-1 during meals [208], in particular during the early phase of GLP-1 secretion

Most patients experience minimal immediate effects on the first day

Always check the expiration date printed on the box or pens to determine how long semaglutide will last in the fridge