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For researchers building a comprehensive IGF axis research workflow, the standard approach is to use IGF-1 LR3 as the primary tool for sustained IGF1R activation studies, native IGF-1 for short-pulse studies where IGFBP biology is itself the research question, and DES IGF-1 for the narrow set of experiments requiring receptor activation with rapid washout

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In some cases, reduced appetite may make it more difficult to meet energy or protein needs required to support training adaptation

Overall, more human clinical trials need to be conducted to guarantee the efficacy of copper peptides