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Published pharmacokinetic research indicates that orally administered berberine, for example, faces substantial first-pass metabolism that may affect the amount reaching target tissues.

Its important to know that over-the-counter (OTC) dietary supplements are not reviewed or approved by the FDA

Clin Interv Aging 2:189199 Ellis JA, Sinclair R, Harrap SB (2002) Androgenetic alopecia: pathogenesis and potential for therapy

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