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Given that the Phase I clinical trial in IPF demonstrated a reduction of senescent cells and SASP within eleven days after a single treatment of D+Q, and improvements in physiological outcomes after 10 weeks (105), we reasoned that a three-month period would provide important feasibility, compliance and efficacy data, as well as potentially reveal other cognitive and biomarker effects useful for designing a larger study
Are they higher
Acting on insulin and glucagon levels, incretins, and thus TZP, may have indirect effects also on the liver and muscle (53), modulating triglycerides (TG) release and favor its clearance (53) and deposition in white adipose tissue (WAT)
Simple timing framework Baseline Discuss baseline labs before starting, especially with diabetes, retinopathy, sleep apnea, edema, cancer history, thyroid disease, or glucose intolerance
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