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N Engl J Med (2013) 369(9):84051.10.1056/NEJMra1208623 16 SingerMDeutschmanCSSeymourCWShankar-HariMAnnaneDBauerMet alThe Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

A portion of superoxide combines with nitric oxide (NO) to form peroxynitrite (ONOO )

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This aligns with the findings of a previous study that showed an increased risk of major CI in type-2 diabetes patients with rising HbA 1c (a proxy for poor glycaemic control) compared to those with lower levels [38]