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But semaglutide works through a single pathway, the GLP-1 receptor, and that single-pathway approach comes with inherent limitations in how much weight it can help someone lose and what metabolic benefits it can deliver beyond appetite suppression

NNMT stands for nicotinamide N-methyltransferase

Although the exact mechanism for this weight-reducing effect is unknown, the proposed mechanism includes alterated perception of taste due to carbonic anhydrase activity and modulation of dopamine and serotonin levels in the brain [241, 244, 245].Empatic has shown promising results in phase 2 clinical trials [241] (Table 2 )