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Front Endocrinol (Lausanne) 12:645507 Ahrn B, Atkin SL, Charpentier G et al (2018) Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or Gastrointestinal adverse events in the SUSTAIN 1 to 5 trials

Others who have never had acid reflux before may develop mild symptoms while taking the medication

Ammonia readily crosses the blood-brain barrier and is thought to inhibit glutamate uptake, thereby increasing extracellular glutamate concentrations in the brain and resulting in activation of NMDA receptors

While the human data on thermogenesis is more modest, the fat oxidation effects are real and measurable