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This cationic polymer-based nanoformulation probably creates an inflammatory environment that further activates cytotoxic cells against cancer ( Another study has formulated amphiphilic polyglutamic acid-based NPs (F/ANs), encapsulated within fenofibrate and surface-modified with an anti-CD3e f (ab ' )2 fragment (aCD3/F/ANs) to stimulate effector T cells for anti-tumor efficacy (Figure 2)

Interestingly, under stress conditions, the inhibition of the mTORC1 pathway stimulates nuclear translocation of the microphthalmia-associated transcription factor (Mitf), which is essential at multiple stages of the melanocyte life cycle

Folate Deficiency Causes Uracil Misincorporation into Human DNA and Chromosome Breakage: Implications for Cancer and Neuronal Damage

Circulation 150 , 10301049 (2024)