Key points RNA strands containing modified nucleotides are produced by using solid-phase synthesis for conjugation with multiple chemotherapeutic prodrugs, including camptothecin, paclitaxel and SN38, by copper-chelated click chemistry, where copper is easily removed during purification due to its much smaller size compared to RNA before assembling the 4WJ RNA nanoparticles, which can be loaded with up to 24 drug molecules per nanoparticle
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In laboratory and neuroscience research models, DSIP is commonly studied for
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