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676 The oncogene c-Myc directly upregulates a suite of glycolytic genes (HK2, PFK1, TPI, GAPDH, ENO, LDHA, and MCT1), intensifies glycolytic flux in cancer cells, 663,677,678 and stabilizes HIF-1 under normoxic conditions by inhibiting its proteasomal degradation through interaction with the von HippelLindau protein

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A 2024 meta-analysis with 47 studies (28 studies comparing XOR inhibitors vs

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Under nutrient-rich conditions, mammalian TORC1 (mTORC1) suppresses activity of the ULK complex via ULK1/2 and ATG13 phosphorylation 15, 16

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