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6 Results from a systematic review and meta-analysis study showed that following discontinuation of weight management medications: Patients are estimated to return to baseline weight within 1.7 years 1,** Results from that same study also highlighted that following discontinuation of weight management medications: Cardiometabolic benefits may be lost, with markers estimated to return to baseline within 1.4 years 1,** Ongoing obesity treatment is needed for maintaining weight loss and improvements in cardiometabolic markers 4 Addressing Discontinuation Starts With Understanding What May Influence Adherence and Persistence 5 Long-term adherence is shaped by multiple, interconnected factorsand ongoing research continues to explore how challenges may interact over time

Lateral hypothalamic circuits for feeding and reward

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