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UK guidance (MHRA and NICE) advises checking B12 levels in patients on metformin who develop symptoms of deficiency (anaemia, neuropathy) and considering periodic monitoring in those on long-term therapy

The gingiva, palate, lateral tongue, and buccal mucosa are commonly involved sites

Clinical observations document improvements in hair count, hair diameter, and overall scalp coverage in subjects using GHK-Cu for androgenetic alopecia, though the peptide's effectiveness appears optimized when applied consistently over several months