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It might mean the dose is no longer sufficient, protein has dropped too low, or stress and sleep have deteriorated enough to override the medication's effects

[DOI] [PubMed] [Google Scholar] 267.Sikiri P., Seiwerth S., Grabarevi Z., Rucman R., Petek M., Jagi V., Turkovi B., Rotkvi I., Mise S., Zorici I., et al

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