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However, excessive or aberrant production of inflammatory mediators caused by dysregulated PRR signaling pathways could contribute to the progression of various diseases ( 4.1 Autoinflammatory diseases Autoinflammatory diseases comprise a diverse group of disorders driven by innate immune system dysregulation ( cataloging more than 50 monogenic disorders to date, with additional categories continually emerging ( Table 1 )

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Given that there is no known mechanism by which blood cells can take up intact glutathione from the plasma, it can only be assumed that it will stay in the plasma until it is eventually degraded

Aug 15 2012;72(16):4238-4249